This research is supported by a Marie Curie Action

This research is supported by a Marie Curie Action
This research has received funding from the People Programme (Marie Curie Actions) of the EU (FP7/2007-2013) under REA grant agreement nº PIEF-GA-2013-622413

Saturday, 26 November 2016

Publication in Chemical Society Reviews (this post is for specialists only)

Recently, it has been published in Chemical Society Reviews a review I have been involved with my lab mates Lydia and Pernille.
For those who are familiar with organic chemistry, you will find the link to the original article below. Hope you enjoy reading it!

Find below the abstract:

Organocatalysis as a paint palette for asymmetric cycloaddition reactions.
Cycloaddition reactions are among the most important tools for the construction of cyclic compounds in organic synthesis, since these reactions are vital to access natural products and biologically active compounds. Organocatalysis plays an increasingly pivotal role in these reactions, often allowing several stereocenters to be selectively created and integrated in the target molecule. Among the large number of efficient types of organocatalysts available, the diarylprolinol silyl ethers have been established as one of the most frequently used in aminocatalysis allowing for novel activation modes and reaction concepts. In this review, we will focus on the different activation modes made available by the diarylprolinol silyl ether system with the aim of highlighting their applicability in asymmetric cycloadditions for the assembly of complex molecular architectures.

Graphical abstract: Asymmetric cycloaddition reactions catalysed by diarylprolinol silyl ethers

Asymmetric cycloaddition reactions catalysed by diarylprolinol silyl ethers
Lydia Klier, Fernando Tur, Pernille H. Poulsen and Karl Anker Jørgensen
Chem. Soc. Rev., 2017, Advance Article
DOI: 10.1039/C6CS00713A, Review Article

Publication in Chemistry: A European Journal (this post is for specialists only)

Recently, it has been published in Chemistry: A European Journal research I have been involved with my lab mates Line, Marta, Jakob and Kim.
For those who are familiar with organic chemistry, you will find the link to the original article below. Hope you enjoy reading it!

Link to full-size graphical abstract

Synergistic Catalysis for the Asymmetric [3+2] Cycloaddition of Vinyl Aziridines with α,β-Unsaturated Aldehydes

Line Næsborg, Dr. Fernando Tur, Dr. Marta Meazza, Jakob Blom, Dr. Kim Søholm Halskov and Prof. Dr. Karl Anker Jørgensen

DOI: 10.1002/chem.201604995

Find below the abstract:

The first asymmetric [3+2] cycloaddition of vinyl aziridines with α,β-unsaturated aldehydes, based on synergistic catalysis, is disclosed. This methodology allows the formation of attractive pyrrolidine structures in good yields (up to 84 %), moderate diastereoselectivity, and high enantioselectivity values (up to >99 % ee). Additionally, a tricyclic pyrrolidine core structure found in biologically active molecules was synthesized in a one-pot fashion by using the presented reaction concept. Finally, a mechanistic proposal is outlined.





Tuesday, 20 September 2016

Synthesis of Tetrakis(triphenylphosphine)palladium(0) (this post is only for specialists)

Here you will find a link to a video prepared by my lab mate Niels Hammer.

It describes the synthesis of Tetrakis(triphenylphosphine)palladium(0). It is the chemical compound of formula Pd[P(C6H5)3]4, often abbreviated Pd(PPh3)4. It is a bright yellow crystalline solid that becomes brown upon decomposition in air. Pd(PPh3)4 is widely used as a catalyst for palladium-catalyzed coupling reactions.



Reference: Coulson, D. R. Inorg. Synth. 1972, 13, 121.

IMPORTANT NOTE:

This post contain information about how to prepare a chemical compound. The procedure described in this video is  intended for use only by persons with prior training in experimental organic chemistry. All hazardous materials should be handled using the standard procedures for work with chemicals. All chemical waste should be disposed of in accordance with local regulations.
This procedure must be conducted at one's own risk. Hereby, the owner of this blog disclaim any liability for any injuries or damages claimed to have resulted from or related in any way to the procedure described herein.

Sunday, 8 May 2016

Publication in Organic Letters (this post is for specialists only)

Recently, it has been published in Organic Letters research I have been involved with my lab mates Kim, and Line.
For those who are familiar with organic chemistry, you will find the link to the original article below. Hope you enjoy reading it!


Asymmetric [3 + 2] Cycloaddition of Vinylcyclopropanes and α,β-Unsaturated Aldehydes by Synergistic Palladium and Organocatalysis

Kim Søholm Halskov, Line Næsborg, Fernando Tur, and Karl Anker Jørgensen
Organic Letters 2016 18 (9), 2220-2223
DOI: 10.1021/acs.orglett.6b00852



Aarhus University

Aarhus University
Aarhus University website

Center for Catalysis, AU

Center for Catalysis, AU
Center for Catalysis, AU website

Marie Curie Actions

Marie Curie Actions
Marie Curie Actions website